The Xuanaci are a tribe of Indians that live in the Amazon. The twins encounter them in the Eye of the Forest. They are noted for their more violent and cannibalistic tendencies, trapping other humans and beheading their prisoners. Raw pirhannas that have just feasted on human flesh is a delicacy for the Xuanci. Later, they capture the twins and were planning to feed them to pirhannas. It was the Xuanaci who shrunk Sicky's head and painted his head. Because they encountered Sicky before, they were intelligent enough to cover his tattoo with rubber latex from the Hevea tree. During the raid of Pizarro, they fought with one another for dominance. They lose their old chief, who pushed them toward their war-like ways. Sicky later became the chief to persuade them to give up their violent ways.

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